Ontology Protein Qualifier GO Name Evidence Code Reference ID With ID Quotation Tissue Name of protein/gene Species Date Function A1X4Q0 GO:0022828 phosphorylation-gated channel activity TAS PUBMED 18548270 PMCA 3a H. sapiens Function A1X4Q0 GO:0005080 protein kinase C binding TAS PUBMED 18548270 PMCA 3a H. sapiens Process P17325 GO:0032583 regulation of gene-specific transcription TAS PUBMED 20431962 sulfiredoxin activator protein 1 (AP-1) R. norvegicus Process P70658 tumor angiogenesis IMP 15180966 CXCR4 M. musculus Process P70658 tumor growth IMP 15180966 lung/prostate cancer CXCR4 M. musculus Process P70658 tumor metastasis IMP 15180966 lung/prostate cancer CXCR4 M. musculus Process Q9WV56 CD31/PECAM1+ (blood vessel?) cell proliferation IDA PUBMED 20406889 BMP9 M. musculus Process Q9WV56 negative regulation of endothelial sheet formation IDA PUBMED 20406889 BMP9 M. musculus Process  P16305 GO:0007610 behavior TAS 17021187 GABA-A receptor alpha 6 M. musculus Process  P26048 GO:0007610 behavior TAS 17021187 GABA-A receptor alpha 2 M. musculus Process  P62812 GO:0007610 behavior TAS 17021187 GABA-A receptor alpha 1 M. musculus Process  P63080 GO:0007610 behavior TAS 17021187 GABA-A receptor beta 3 M. musculus Process  P63080 ear hair cell protection IMP 17021187 GABA-A receptor beta 3 M. musculus Process  P63080 spiral ganglion cell protection/morphogenesis IMP 17021187 in the cochlea GABA-A receptor beta 3 M. musculus Process  P63080 type IV fibrocyte cell protection/morphogenesis IMP 17021187 GABA-A receptor beta 3 M. musculus Process  P63080 spiral limbus morphogenesis IMP 17021187 GABA-A receptor beta 3 M. musculus Process  P63080 afferent nerve protection IMP 17021187 inner ear hair cells in the cochlea GABA-A receptor beta 3 M. musculus Process  P63137 GO:0007610 behavior TAS 17021187 GABA-A receptor beta 2 M. musculus Process  P63137 ear hair cell protection IMP 17021187 GABA-A receptor beta 2 M. musculus Process  P63137 spiral ganglion cell protection/morphogenesis IMP 17021187 in the cochlea GABA-A receptor beta 2 M. musculus Process  P63137 type IV fibrocyte cell protection/morphogenesis IMP 17021187 GABA-A receptor beta 2 M. musculus Process  P63137 spiral limbus morphogenesis IMP 17021187 GABA-A receptor beta 2 M. musculus Process  Q8BHJ7 GO:0007610 behavior TAS 17021187 GABA-A receptor alpha 5 M. musculus Process  Q8BHJ7 ear hair cell protection IMP 17021187 GABA-A receptor alpha 5 M. musculus Process  Q8BHJ7 spiral ganglion cell protection/morphogenesis IMP 17021187 in the cochlea GABA-A receptor alpha 5 M. musculus Process  Q8BHJ7 type IV fibrocyte cell protection/morphogenesis IMP 17021187 GABA-A receptor alpha 5 M. musculus Process  Q8BHJ7 spiral limbus morphogenesis IMP 17021187 GABA-A receptor alpha 5 M. musculus Function A1X4P8 GO:0022828 phosphorylation-gated channel activity TAS PUBMED 18548270 PMCA 2a H. sapiens Function A1X4P8 GO:0005080 protein kinase C binding TAS PUBMED 18548270 PMCA 2a H. sapiens Function A1X4Q1 GO:0022828 phosphorylation-gated channel activity TAS PUBMED 18548270 PMCA 4b H. sapiens Function A1X4Q1 GO:0005080 protein kinase C binding TAS PUBMED 18548270 PMCA 4b H. sapiens Process A-CREB GO:0032582 negative regulation of gene-specific transcription IMP 19252502 ppargc1b osteoclats CREB M. musculus Process A-CREB GO:0045671 negative regulation of osteoclast differentiation IDA 19252502 A-CREB M. musculus Process activin signaling anterior positional identity of neuron differentiation TAS PUBMED 20431962 “Neurons generated from hESCs under chemically defined conditions in the absence of exogenous morphogens including retinoic acid tend to differentiate towards an anterior positional identity [10] as has been found for mouse hESCs [11].” in the brain activin signaling H. sapiens Process activins GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 of "smad2, smad3" activins ? Function ADAM22 GO:0004888 transmembrane receptor activity TAS 20463223 LGI1 ADAM22 R. norvegicus Function ADAM23 GO:0004888 transmembrane receptor activity TAS 20463223 LGI1 ADAM23 R. norvegicus Process ALK-1-Smad1/5/8 GO:0010595 positive regulation of endothelial cell migration TAS PUBMED 20406889 ALK-1-Smad1/5/8 M. musculus Process ALK-1-Smad1/5/8 GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 ALK-1-Smad1/5/8 M. musculus Function ALK2 GO:0005160 transforming growth factor beta receptor binding TAS PUBMED 18461597 TGFb type II receptor (TbRII) activin receptor-like kinase 2 ? Function ALK2 GO:0070700 BMP receptor binding TAS PUBMED 18461597 BMP type 2 receptors activin receptor-like kinase 2 ? Process ALK2 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 activin receptor-like kinase 2 M. musculus Process ALK2 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 activin receptor-like kinase 2 G. gallus Function ALK2 GO:0005515 protein binding TAS PUBMED 18461597 "TGFb, in the presence of type II TGFb receptor" activin receptor-like kinase 2 G. gallus Process ALK2 GO:0043193 positive regulation of gene-specific transcription IMP PUBMED 18461597 ROCK1 activin receptor-like kinase 2 G. gallus Process ALK2 GO:0060485 mesenchyme development TAS PUBMED 18461597 ALK2 G. gallus Process ALK2 GO:0060317 cardiac epithelial to mesenchymal transition TAS PUBMED 18461597 ALK2 G. gallus Process ALK2 GO:0003181 atrioventricular valve morphogenesis TAS PUBMED 18461597 ALK2 M. musculus Process ALK2 GO:0003199 endocardial cushion to mesenchymal transition involved in valve formation TAS PUBMED 18461597 ALK2 M. musculus Process ALK2 GO:0003200 endocardial cushion to mesenchymal transition involved in heart chamber septation TAS PUBMED 18461597 ALK2 M. musculus Function ALK5 GO:0005515 protein binding TAS PUBMED 18461597 "TGFb, in the presence of type II TGFb receptor" activin receptor-like kinase 5 G. gallus Process ALK5 GO:0043193 positive regulation of gene-specific transcription IMP PUBMED 18461597 ROCK1 activin receptor-like kinase 5 G. gallus Process ALK5 GO:0010718 positive regulation of epithelial to mesenchymal transition IMP PUBMED 18461597 activin receptor-like kinase 5 G. gallus Process ALK5 GO:0060317 cardiac epithelial to mesenchymal transition IMP PUBMED 18461597 activin receptor-like kinase 5 G. gallus Process ALK5 NOT GO:0060485 mesenchyme development TAS PUBMED 18461597 ALK5 G. gallus Process ALK5 GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 18461597 ALK5 G. gallus Process ALK5 GO:0060317 cardiac epithelial to mesenchymal transition TAS PUBMED 18461597 ALK5 G. gallus Process ALK5 (activin receptor-like kinase 5) GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 ALK5 (activin receptor-like kinase 5) M. musculus Process ALK5 activin receptor-like kinase 5 GO:0061032 visceral serous pericardium dev TAS PUBMED 20299672 ALK5 activin receptor-like kinase 5 M. musculus Process ALK5 TGF beta receptor GO:0060947 cardiac vascular smooth muscle cell differentiation TAS PUBMED 20299672 ALK5 TGF beta receptor M. musculus Process ALK5 TGF beta receptor GO:0001974 blood vessel remodeling TAS PUBMED 20299672 ALK5 TGF beta receptor M. musculus Process ALK5 TGF beta receptor GO:0060947 visceral serous pericardium development TAS PUBMED 20299672 ALK5 TGF beta receptor M. musculus Process ALK-5-Smad2/3 GO:0010596 negative regulation of endothelial cell migration TAS PUBMED 20406889 ALK-5-Smad2/3 M. musculus Process ALK-5-Smad2/3 GO:0001937 negative regulation of endothelial cell proliferation TAS PUBMED 20406889 ALK-5-Smad2/3 M. musculus Function Ang-1 GO:0048018 receptor agonist activity TAS PUBMED 20406889 of Tie2 tyrosine kinase receptor Ang-1 R. norvegicus Process Ang-1 GO:0043066 negative regulation of apoptosis TAS PUBMED 20406889 Ang-1 R. norvegicus Process Ang1-Tie2 GO:0042118 endothelial cell activation TAS PUBMED 20406889 Ang1-Tie2 M. musculus Process ang-1-tie-2 signaling GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS PUBMED 20406889 VEGF-VEGFR2 ang-1-tie-2 signaling M. musculus Process ang-1-tie-2 signaling positive regulation of angiopoietin-1-Tie2 signaling TAS PUBMED 20406889 ang-1-tie-2 signaling M. musculus Process ang-1-tie-2 signaling GO:0010595 positive regulation of endothelial cell migration TAS PUBMED 20406889 ang-1-tie-2 signaling M. musculus Process ang-1-tie-2 signaling GO:0001936 regulation of endothelial cell proliferation TAS PUBMED 20406889 ang-1-tie-2 signaling M. musculus Function Ania3/Homer protein GO:0005515 protein binding TAS PUBMED 18548270 PMCA PMCA ? Process apaf1 retina development TAS 20579985 apaf1 ? Process apaf1 lens development TAS 20579985 apaf1 ? Process ATRA GO:0043193 positive regulation of gene-specific transcription IDA 19443732 P10826 (RAR-beta) "NOTE: this article says ATRA Is a ligand of RAR-beta (TAS), which activates chimerin (TAS). Then did an assay measuring chemerin levels of cells treated with different concentrations of ATRA (IDA)" all-trans retinoic acid H. sapiens Process ATRA GO:0043193 positive regulation of gene-specific transcription IDA 19443732 Q99969 (chemerin) "NOTE: this article says ATRA Is a ligand of RAR-beta (TAS), which activates chimerin (TAS). Then did an assay measuring chemerin levels of cells treated with different concentrations of ATRA (IDA)" all-trans retinoic acid H. sapiens Process beta catenin GO:0021846 cell proliferation in forebrain TAS PUBMED 20624590 beta catenin M. musculus Process beta catenin GO:0021879 forebrain neuron differentiation TAS PUBMED 20624590 beta catenin M. musculus Process beta catenin GO:0030182 neuron differentiation TAS PUBMED 20624590 beta catenin M. musculus Process BMP GO:0010717 regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 Bone morphogenetic protein M. musculus Process BMP GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 bone morphogenetic protein (BMP) ? Process BMP receptors GO:0010717 regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 Bone morphogenetic protein receptors M. musculus Process BMP signaling pathway GO:0043010 camera-type eye development TAS 20579985 BMP signaling pathway ? Process "BMP type I receptors (ALK2, ALK3, ALK6)" GO:0030509 BMP signaling pathway TAS PUBMED 20406889 "BMP type I receptors (ALK2, ALK3, ALK6)" ? Process "BMP type I receptors (ALK2, ALK3, ALK6)" GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 "BMP type I receptors (ALK2, ALK3, ALK6)" ? Process BMP-4 GO:0042118 endothelial cell activation TAS PUBMED 20406889 BMP-4 M. musculus BMP4 signaling early stages of differentiation of progenitor cells NAS PUBMED 20406889 BMP4 signaling ? Process BMP4-ALK3 signaling GO:0001710 mesodermal cell fate commitment TAS PUBMED 20406889 BMP4-ALK3 signaling ? Process BMP-9 GO:0006006 glucose metabolic process TAS PUBMED 20406889 Bone Morphogenetic Protein 9 (BMP-9) R. norvegicus Process BMP-9 GO:0006631 fatty acid metabolic process TAS PUBMED 20406889 Bone Morphogenetic Protein 9 (BMP-9) R. norvegicus Process BMP-9 primary hepatocyte proliferation TAS PUBMED 20406889 Bone Morphogenetic Protein 9 (BMP-9) R. norvegicus Process BMP-9 GO:0001937 negative regulation of endothelial cell proliferation TAS PUBMED 20406889 BMP-9 ? BMP9 signaling occurs only in fully differentiated endothelial cells NAS PUBMED 20406889 BMP9 signaling ? Process BMP-9-ALK-1 GO:0030509 BMP signaling pathway NAS PUBMED 20406889 BMP-9-ALK-1 M. musculus Process BMPR1 (ALK2) GO:0060317 cardiac epithelial to mesenchymal transition TAS PUBMED 18461597 Bone morphogenetic protein type 1 receptor (activin receptor-like kinase 2) G. gallus Function BMPs GO:0070700 BMP receptor binding TAS PUBMED 20406889 "BMP type 1 receptors ALK2, ALK3, and ALK6" BMP (bone morphogenetic protein) ? Process BMPs GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation TAS PUBMED 20406889 BMP (bone morphogenetic protein) ? Process BMPs GO:0030510 regulation of BMP signaling pathway TAS PUBMED 20406889 BMP (bone morphogenetic protein) ? Process BMPs GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 BMP (bone morphogenetic protein) ? Process BMPs GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 of "smad2, smad3" Bone Morphogenetic Proteins (BMPs) ? Process Ca2+ GO:0032583 regulation of gene-specific transcription TAS PUBMED 18548270 "PMCA and isoforms. Upregulation of isoforms 2 and 3, truncated version of isoform 1, and isoform 4 disappears" Calcium ion R. norvegicus Function calpain GO:0005515 protein binding TAS PUBMED 18548270 PMCA calpain H. sapiens Process calpain GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA calpain H. sapiens Process calpain permanent activation of PMCA TAS PUBMED 18548270 PMCA calpain H. sapiens Function CASK GO:0005515 protein binding TAS PUBMED 18548270 PMCA PMCA ? Process caspase3 retina development TAS 20579985 caspase3 ? Process caspase3 lens development TAS 20579985 caspase3 ? Process caspases GO:0042981 regulation of apoptosis TAS PUBMED 20431962 caspases ? Process caspases GO:0034205 beta-amyloid formation TAS PUBMED 20431962 caspases M. musculus Process caspases Tau cleavage TAS PUBMED 20431962 caspases M. musculus Process chd GO:0060900 embryonic camera-type eye formation IMP PUBMED 20823067 chd X. laevis Process chd GO:0060898 camera-type eye field cell fate commitment IMP PUBMED 20823067 chd X. laevis Process chd GO:0007355 anterior region determination IMP PUBMED 20823067 chd X. laevis Process CREB GO:0043193 positive regulation of gene-specific transcription IMP 19252502 ppargc1b osteoclasts CREB M. musculus Process CREB GO:0030316 osteoclast differentiation IDA 19252502 CREB M. musculus Function C-terminal PDZ ligand of human somatostatin receptor 3 GO:0005515 protein binding TAS PUBMED 20431962 PDZ protein MUPP1 C-terminal PDZ ligand of human somatostatin receptor 3 H. sapiens Function C-terminal PDZ ligand of human somatostatin receptor 3 NOT GO:0005515 protein binding TAS PUBMED 20431962 PDZ protein MUPP1 ( Q8VBX6) C-terminal PDZ ligand of human somatostatin receptor 3 M. musculus Process CXCL12 hemapoietic cell migration TAS 15180966 to the bone marrow CXCL12 ? Process CXCR4 hemapoietic cell migration TAS 15180966 to the bone marrow CXCR4 ? Process CXCR4 neoplastic processes TAS 15180966 CXCR4 ? Process downregulation of bone morphogenetic protein signaling GO:0060947 : cardiac vascular smooth muscle cell differentiation NAS PUBMED 20299672 downregulation of bone morphogenetic protein signaling M. musculus Process downregulation of bone morphogenetic protein signaling GO:0001974 blood vessel remodeling NAS PUBMED 20299672 downregulation of bone morphogenetic protein signaling M. musculus Function Endoglin GO:0015026 coreceptor activity TAS PUBMED 20406889 for TGF beta family signals Endoglin ? Human or porcine? Process endoglin GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 18461597 endoglin G. gallus Process endoglin GO:0060317 cardiac epithelial to mesenchymal transition TAS PUBMED 18461597 endoglin G. gallus Process "Epicardial-expressed FGFs (-1, -2, -4, -9, -16, -20)" GO:0060038 cardiac muscle cell proliferation NAS PUBMED 20299672 "Epicardial-expressed FGFs (-1, -2, -4, -9, -16, -20)" M. musculus Process Erythropoietin GO:0060045 positive regulation of cardiac muscle cell proliferation TAS PUBMED 20299672 Erythropoietin G. gallus Process Erythropoietin receptor (EpoR) GO:0060045 positive regulation of cardiac muscle cell proliferation TAS PUBMED 20299672 Erythropoietin receptor (EpoR) G. gallus Process Ets-1 GO:0060982 coronary artery morphogenesis TAS PUBMED 20299672 erythroblastosis virus oncogene G. gallus Process Ets-1 GO:0001569 patterning of blood vessels TAS PUBMED 20299672 erythroblastosis virus oncogene G. gallus Process FGF GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 FGF M. musculus Process FGF (myocardial) GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20299672 of FGFR1 in the epicardium "epicardium, myocardium" FGF (myocardial) quail Process FGF (myocardial) GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20299672 of FGFR1 in the epicardium "epicardium, myocardium" FGF (myocardial) G. gallus Process FGF signaling GO:0060038 cardiac muscle cell proliferation NAS PUBMED 20299672 FGF signaling NA (but specific FGF experiments in M. musculus mentioned same paragraph) Process FGF signals GO:0009952 anterior/posterior pattern formation IMP PUBMED 20823067 neural tissues FGF signals X. laevis Process "FGF, myocardial" GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20299672 in the subepicardium "FGF, myocardial" G. gallus Process "FGF, myocardial" GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20299672 in the subepicardium "FGF, myocardial" Quail Process FGF2 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 FGF2 Quail Process FGF2 GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20299672 FGF2 Quail Process FGF2 GO:0010595 positive regulation of endothelial cell migration TAS PUBMED 20299672 FGF2 Quail Process FGF2 GO:0035148 tube formation TAS PUBMED 20299672 FGF2 Quail Process FGF7 GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 FGF7 G. gallus Process FGFR1 GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 FGFR1 Quail Process Fibroblast Growth Factors GO:0060045 positive regulation of cardiac muscle cell proliferation NAS PUBMED 20299672 Retinoic acid ? GABAa receptor antagonists protection from excitotoxicity TAS 17021187 in cerebellar granule cells GABAa receptor antagonists M. musculus Process GTP-Rho GO:0007266 Rho protein signal transduction TAS PUBMED 18461597 "“GTP-Rho activates its downstream effectors, the Rho kinases (ROCK1 and ROCK2), which have been found to regulate actin organization, thereby controlling a wide range of fundamental cell functions such as proliferation, contraction, and motility (Matsui et al., 1996; Loirand et al., 2006).”" GTP-Rho B. taurus Process GTP-Rho GO:0030036 actin cytoskeleton organization TAS PUBMED 18461597 "“GTP-Rho activates its downstream effectors, the Rho kinases (ROCK1 and ROCK2), which have been found to regulate actin organization, thereby controlling a wide range of fundamental cell functions such as proliferation, contraction, and motility (Matsui et al., 1996; Loirand et al., 2006).”" GTP-Rho B. taurus Process GTP-Rho GO:0008283 cell proliferation TAS PUBMED 18461597 "“GTP-Rho activates its downstream effectors, the Rho kinases (ROCK1 and ROCK2), which have been found to regulate actin organization, thereby controlling a wide range of fundamental cell functions such as proliferation, contraction, and motility (Matsui et al., 1996; Loirand et al., 2006).”" GTP-Rho B. taurus Process GTP-Rho GO:0070252 actin-mediated cell contraction TAS PUBMED 18461597 "“GTP-Rho activates its downstream effectors, the Rho kinases (ROCK1 and ROCK2), which have been found to regulate actin organization, thereby controlling a wide range of fundamental cell functions such as proliferation, contraction, and motility (Matsui et al., 1996; Loirand et al., 2006).”" GTP-Rho B. taurus Process GTP-Rho GO:0060327 cytoplasmic actin-based contraction involved in cell TAS PUBMED 18461597 "“GTP-Rho activates its downstream effectors, the Rho kinases (ROCK1 and ROCK2), which have been found to regulate actin organization, thereby controlling a wide range of fundamental cell functions such as proliferation, contraction, and motility (Matsui et al., 1996; Loirand et al., 2006).”" GTP-Rho B. taurus Process HAMP variant increased risk of Acute Lymphoblastic Leukemia IMP 19711434 in females AMP SNP variant H. sapiens Process Hedgehog signaling GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 Hedgehog signaling M. musculus Process Hedgehog signaling GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 Hedgehog signaling M. musculus Process Hedgehog signaling intramyocardial ephrinB2-positive vessel development TAS PUBMED 20299672 Hedgehog signaling M. musculus Process Hedgehog signaling GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20299672 of "VEGF-A, -B, and –C, and angiopoietin-2" in the heart Hedgehog signaling M. musculus Process Hedgehog signaling GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 Hedgehog signaling M. musculus Process HFE variant C282Y positive regulation of fetal birth weight IMP 19711434 "in males, esp if mother has variant" HFE variant C282Y H. sapiens Process HFE variant C282Y positive regulation of body iron content TAS 19711434 HFE variant C282Y H. sapiens Process HFE variant C282Y negative regulation of fetal birth weight IMP 19711434 in females HFE variant C282Y H. sapiens Process HFE variant H63D positive regulation of fetal birth weight IMP 19711434 "in males, esp if mother has variant" HFE variant H63D H. sapiens Process HFE variant H63D positive regulation of body iron content TAS 19711434 HFE variant H63D H. sapiens Process HFE variant H63D negative regulation of fetal birth weight IMP 19711434 in females HFE variant H63D H. sapiens Process HFE variants increased risk of Acute Lymphoblastic Leukemia IMP 19711434 in females "HFE variants included in this analysis were rs1800562, rs1799945, and rs9366637 (C282Y, H63D, and IVS1, respectively)." H. sapiens Process Hipk family GO:0017015 regulation of transforming growth factor beta receptor signaling pathway TAS 20579985 homeodomain-interacting protein kinase (HIPK) family ? Process Hipk family GO:0030510 regulation of BMP signaling pathway TAS 20579985 homeodomain-interacting protein kinase (HIPK) family ? Process Hipk family GO:0008593 regulation of Notch signaling pathway TAS 20579985 homeodomain-interacting protein kinase (HIPK) family ? Process Hipk family GO:0030111 regulation of Wnt receptor signaling pathway TAS 20579985 homeodomain-interacting protein kinase (HIPK) family ? Process Hipk family GO:0043010 camera-type eye development TAS 20579985 homeodomain-interacting protein kinase (HIPK) family ? Process Hipk family GO:0043065 positive regulation of apoptosis TAS 20579985 homeodomain-interacting protein kinase (HIPK) family ? Function IRE GO:0005515 protein binding IDA 19252502 Q811J3 (IRP2) IRE/ERN M. musculus Process IRE GO:0030316 osteoclast differentiation IEP 19252502 IRE/ERN M. musculus Process kcne2 GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20798505 kcne2 R. norvegicus Process kcne2 GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20798505 kcne2 M. musculus Process kcne2 GO:0042403 thyroid hormone metabolic process TAS PUBMED 20798505 kcne2 R. norvegicus Process kcne2 GO:0043193 thyroid hormone metabolic process TAS PUBMED 20798505 kcne2 M. musculus Process Kv GO:0001508 regulation of action potential TAS PUBMED 20798505 heart Voltage--dependent K+ channels ? Process Kv GO:0019228 regulation of action potential in neuron TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0014861 regulation of skeletal muscle contraction via membrane TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0030073 insulin secretion TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0006813 potassium ion transport TAS PUBMED 20798505 epithelium Voltage--dependent K+ channels ? Process Kv GO:0006884 cell volume homeostasis TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0001775 cell activation TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0008283 cell proliferation TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0030154 cell differentiation TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0051289 protein homotetramerization TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0051290 protein heterotetramerization TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv GO:0044214 fully spanning the plasma membrane TAS PUBMED 20798505 Voltage--dependent K+ channels ? Process Kv1.3 GO:0001775 cell activation TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 ? Process Kv1.3 GO:0008283 cell proliferation TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 ? Process Kv1.3 GO:0030154 cell differentiation TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 ? Process Kv1.5 GO:0001775 cell activation TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 ? Process Kv1.5 GO:0008283 cell proliferation TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 ? Process Kv1.5 GO:0030154 cell differentiation TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 ? Process Kv1.5 GO:0042403 thyroid hormone metabolic process TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 R. norvegicus Process Kv1.5 GO:0043193 thyroid hormone metabolic process TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 M. musculus Process LGI1 mutations autosomal dominant lateral temporal lobe epilepsy (ADTLE) TAS 20463223 mutations in leucine-rich glioma inactivated (LGI1) H. sapiens Function MAGUK family GO:0005515 protein binding TAS PUBMED 18548270 PMCA PMCA ? Process Mef2 GO:0007420 brain development IEP 7643214 "myocyte enhancer factor 2 (""Mef2"")" M. musculus Process NCX genes GO:0006874 cellular calcium ion homeostasis TAS PUBMED 20431962 "“The NCX genes are important for neuronal Ca2+ homeostasis, particularly when substantial Ca2+ influx takes place, for example, following an excitotoxic insult.”" neurons NCX genes ? Process NCX3 GO:0051283 negative regulation of sequestering of calcium ion TAS PUBMED 20431962 neurons NCX3 ? Process neurotrophic factors GO:0043526 neuroprotection TAS PUBMED 20431962 neurotrophic factors ? Process neurotrophic factors GO:0010468 regulation of gene expression TAS PUBMED 20431962 neurotrophic factors ? Process NMDA receptor activity GO:0043526 neuroprotection TAS PUBMED 20431962 NMDA receptor activity ? Process NMDA receptor activity GO:0010468 regulation of gene expression TAS PUBMED 20431962 NMDA receptor activity ? Process NMDAR activity GO:0032583 regulation of gene-specific transcription TAS PUBMED 20431962 sulfiredoxin NMDAR activity R. norvegicus Process Nodal GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 of "smad2, smad3" Nodal ? Process nodal signaling anterior positional identity of neuron differentiation TAS PUBMED 20431962 “Neurons generated from hESCs under chemically defined conditions in the absence of exogenous morphogens including retinoic acid tend to differentiate towards an anterior positional identity [10] as has been found for mouse hESCs [11].” in the brain nodal signaling H. sapiens Process Notch signaling pathway GO:0043010 camera-type eye development TAS 20579985 Notch signaling pathway ? Process Notch signaling pathway GO:0032582 negative regulation of gene-specific transcription TAS 20579985 P57Kip2 Notch signaling pathway ? Process Notch signaling pathway GO:0002089 lens morphogenesis in camera-type eye TAS 20579985 Notch signaling pathway ? 8.3 "From now on, all TAS annotations will go into GONE" Process O08538 GO:0001525 angiogenesis TAS PUBMED 20299672 Ang-1 (Angiopoietin 1) M. musculus Process O08538 positive regulation of angiopoietin-1-Tie2 signaling TAS PUBMED 20406889 angiopoietin-1 M. musculus Function O08538 GO:0048018 receptor agonist activity TAS PUBMED 20406889 of Tie2 tyrosine kinase receptor Ang-1 M. musculus Process O08538 GO:0043066 negative regulation of apoptosis TAS PUBMED 20406889 Ang-1 M. musculus Process O09118 GO:0030517 negative regulation of axon extension TAS 20357111 Netrin1 M. musculus Function O75970 GO:0005515 protein binding TAS PUBMED 20431962 C-terminal PDZ ligand of human somatostatin receptor 3 PDZ protein MUPP1 H. sapiens Process O88904 retina ganglion patterning IMP 20579985 Hipk1 M. musculus O95970 increased risk for autosomal dominant lateral temporal epilepsy (ADLTE) TAS 20463223 extracellular leucine-rich glioma inactivated (LGI1) H. sapiens Function O95970 GO:0005102 receptor binding TAS 20463223 ADAM22 leucine-rich glioma inactivated (LGI1) R. norvegicus Function O95970 GO:0005102 receptor binding TAS 20463223 ADAM23 leucine-rich glioma inactivated (LGI1) R. norvegicus Process O95970 GO:0090129 positive regulation of synapse maturation TAS 20463223 by regulating cell surface AMPA receptors leucine-rich glioma inactivated (LGI1) R. norvegicus O95970 stabilizing levels of cell surface AMPA receptors TAS 20463223 by regulating cell surface AMPA receptors """Another proteomic study identified the transmembrane proteins ADAM22 and ADAM23 as LGI1 receptors and suggested that LGI1 modulates synaptic function by stabilizing levels of cell surface AMPA receptors (Fukata et al., 2006 ).""" in excitatory synapses in the hippocampus leucine-rich glioma inactivated (LGI1) R. norvegicus Process O95970 GO:0021766 hippocampus development TAS 20463223 in excitatory synapses in the hippocampus leucine-rich glioma inactivated (LGI1) H. sapiens Process O95970 GO:0016322 neuron remodeling TAS 20463223 leucine-rich glioma inactivated (LGI1) H. sapiens Process O95970 GO:0090129 positive regulation of synapse maturation TAS 20463223 leucine-rich glioma inactivated (LGI1) H. sapiens Process O95970 GO:0007268 synaptic transmission TAS 20463223 leucine-rich glioma inactivated (LGI1) H. sapiens Process O95970 GO:0016358 dendrite development TAS 20463223 leucine-rich glioma inactivated (LGI1) H. sapiens Process O95970 GO:0060074 synapse maturation TAS 20463223 glutamatergic synapse leucine-rich glioma inactivated (LGI1) H. sapiens Process P01019 GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 18461597 ROCK coronary vascular smooth muscle cells angiotensin II H. sapiens Process P01308 GO:2000252 negative regulation of feeding behavior IDA 17957153 cord leptin Leptin H. sapiens Process P01584 GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 18461597 ROCK coronary vascular smooth muscle cells Interleukin 1b H. sapiens Process P06804 GO:0048566 embryonic digestive tract development IEP 20875417 TNF-alpha M. musculus Process P10826 GO:0043193 positive regulation of gene-specific transcription TAS 19443732 Q99969 (chemerin) P10826 (RAR-beta) H. sapiens Process P10826 GO:0043193 positive regulation of gene-specific transcription IDA 19443732 Q99969 (chemerin) "NOTE: this article says ATRA Is a ligand of RAR-beta (TAS), which activates chimerin (TAS). Then did an assay measuring chemerin levels of cells treated with different concentrations of ATRA (IDA)" P10826 (RAR-beta) H. sapiens Function P11506 GO:0005515 protein binding TAS PUBMED 17234811 calmodulin PMCA2 Plasma membrane Ca2 pump type 2 R. norvegicus Process P12025 GO:0030154 cell differentiation TAS PUBMED 20346117 Midkine (MK) M. musculus Process P12025 GO:0043005 neuron projection TAS PUBMED 20346117 Midkine (MK) M. musculus Process P12025 GO:0030182 neuron differentiation TAS PUBMED 20346117 Midkine (MK) M. musculus Process P12025 GO:0043526 neuroprotection TAS PUBMED 20346117 Midkine (MK) M. musculus Process P12025 GO:0043005 neuron projection TAS PUBMED 10096022 embryonic neurons Midkine (MK) M. musculus Process P12025 GO:0051919 positive regulation of fibrinolysis TAS PUBMED 10096022 aortic endothelial cells Midkine (MK) M. musculus Process P12025 GO:0007529 establishment of synaptic specificity at neuromuscular junction TAS PUBMED 10096022 Midkine (MK) M. musculus Process P12025 GO:0043526 neuroprotection TAS PUBMED 10096022 in the embryo Midkine (MK) M. musculus Process P12025 GO:0045666 positive regulation of neuron differentiation TAS PUBMED 10096022 Midkine (MK) M. musculus Process P12025 GO:0030593 neutrophil chemotaxis TAS PUBMED 10096022 Midkine (MK) M. musculus Process P12025 GO:0046671 negative regulation of retinal cell programmed cell death TAS PUBMED 10096022 due to excessive light Midkine (MK) M. musculus Process P12025 GO:0007399 nervous system development TAS PUBMED 10096022 Midkine (MK) M. musculus Process p160 Rat sarcoma virus oncogene homolog (Rho)-kinase GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 p160 Rat sarcoma virus oncogene homolog (Rho)-kinase quail Process P16047 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 TGFb3 G. gallus Process P16047 GO:0010718 positive regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 TGFb3 G. gallus Process P16047 GO:0042118 endothelial cell activation TAS PUBMED 18461597 TGFb3 G. gallus Process P16047 GO:0001837 epithelial to mesenchymal transition TAS PUBMED 18461597 transforming growth factor beta 3 G. gallus Process P16047 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 TGFb3 G. gallus Process P16047 GO:0048762 mesenchymal cell differentiation TAS PUBMED 18461597 TGFb3 G. gallus Process P16047 GO:0090131 mesenchyme migration TAS PUBMED 18461597 TGFb3 G. gallus Process P16390 GO:0042391 regulation of membrane potential TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 M. musculus Process P16390 GO:0002443 leukocyte mediated immunity TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 M. musculus Process P16390 GO:0007608 sensory perception of smell TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 M. musculus Function P20033 GO:0042803 protein homodimerization activity NAS PUBMED 20299672 PDGF-A M. musculus Function P20033 GO:0048407 platelet-derived growth factor binding NAS PUBMED 20299672 PDGF-A M. musculus Process P20722 negative regulation of endothelial sheet formation IDA PUBMED 20406889 BMP6 M. musculus Process P20722 GO:0003181 atrioventricular valve morphogenesis TAS PUBMED 18461597 BMP6 M. musculus Process P20722 GO:0003207 cardiac chamber formation TAS PUBMED 18461597 BMP6 M. musculus Process P21274 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 BMP2 M. musculus Process P21274 GO:0003181 atrioventricular valve morphogenesis TAS PUBMED 18461597 BMP2 M. musculus Process P21274 GO:0003207 cardiac chamber formation TAS PUBMED 18461597 BMP2 M. musculus Process P21275 positive regulation of angiopoietin-1-Tie2 signaling TAS PUBMED 20406889 BMP4 M. musculus Process P22001 GO:0042391 regulation of membrane potential TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 (Kv1.3) H. sapiens Process P22001 GO:0002443 leukocyte mediated immunity TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 (Kv1.3) H. sapiens Process P22001 GO:0051290 protein heterotetramerization TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 (Kv1.3) H. sapiens Process P22001 GO:0010906 regulation of glucose metabolic process TAS PUBMED 20798505 Voltage--dependent K+ channel 1.3 (Kv1.3) H. sapiens Process P22460 GO:0051290 protein heterotetramerization TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 (Kv1.5) H. sapiens Process P22460 GO:0055117 regulation of cardiac muscle contraction TAS PUBMED 20798505 Voltage--dependent K+ channel 1.5 (Kv1.5) H. sapiens Process P23359 GO:0003181 atrioventricular valve morphogenesis TAS PUBMED 18461597 BMP7 M. musculus Process P23359 GO:0003207 cardiac chamber formation TAS PUBMED 18461597 BMP7 M. musculus Function P23634 GO:0022828 phosphorylation-gated channel activity TAS PUBMED 18548270 PMCA 4a H. sapiens Function P23634 GO:0005080 protein kinase C binding TAS PUBMED 18548270 PMCA 4a H. sapiens Process P27090 GO:0010718 positive regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 TGFb2 M. musculus Process P27090 GO:0042118 endothelial cell activation TAS PUBMED 18461597 TGFb2 M. musculus Process P27090 GO:0060731 positive regulation of intestinal epithelial structure maintenance IMP 20875417 decreased damage in NEC and hypoxic environment TGF-beta 2 M. musculus Function P29466 GO:0005515 protein binding TAS PUBMED 18548270 PMCA caspase 1 H. sapiens Process P29466 GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA2 caspase 1 H. sapiens Process P29466 GO:0051927 negative regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA2 caspase 1 H. sapiens Process P29466 GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA4 caspase 1 H. sapiens Process P29466 GO:0051927 negative regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA4 caspase 1 H. sapiens Process P29533 Coronary plexus dev TAS PUBMED 20299672 Vascular cell adhesion protein 1 (VCAM1) M. musculus Function P29533 GO:0005515 protein binding TAS PUBMED 20299672 Q00651 Vascular cell adhesion protein 1 (VCAM1) M. musculus Process P29533 GO:0016337 cell-cell adhesion NAS PUBMED 20299672 epicardium/myocardium Vascular cell adhesion protein 1 (VCAM1) M. musculus Process P29533 GO:0060976 coronary vasculature development NAS PUBMED 20299672 Vascular cell adhesion protein 1 (VCAM1) M. musculus Process p300 GO:0004402 histone acetyltransferase activity TAS PUBMED 20299672 transcription factor M. musculus Process p300 GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 20299672 transcription factor M. musculus Process p300 GO:0006338 chromatin remodeling TAS PUBMED 20299672 transcription factor M. musculus Process p300 GO:0003007 heart morphogenesis TAS PUBMED 20299672 transcription factor M. musculus Process p300 GO:0060425 lung morphogenesis TAS PUBMED 20299672 transcription factor M. musculus Process p300 GO:0030324 lung development TAS PUBMED 20299672 transcription factor M. musculus Process p300 GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 transcription factor M. musculus Process P30371 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 TGFb2 G. gallus Process P30371 GO:0010718 positive regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 TGFb2 G. gallus Process P30371 GO:0042118 endothelial cell activation TAS PUBMED 18461597 TGFb2 G. gallus Process P30371 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 TGFb2 G. gallus Process P30371 GO:0042118 endothelial cell activation TAS PUBMED 18461597 TGFb2 G. gallus Process P30556 GO:0043193 positive regulation of gene-specific transcription TAS PUBMED 18461597 ROCK coronary vascular smooth muscle cells AII type 1 receptor H. sapiens Process P31016 GO:0045428 regulation of nitric oxide biosynthetic process TAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ domains on PSD95 R. norvegicus Process P31016 GO:0042981 regulation of apoptosis TAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ domains on PSD95 R. norvegicus Process P31016 GO:0050999 regulation of nitric-oxide synthase activity TAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ domains on PSD95 R. norvegicus Function P31240 GO:0042803 protein homodimerization activity NAS PUBMED 20299672 PDGF-B M. musculus Function P31240 GO:0048407 platelet-derived growth factor binding NAS PUBMED 20299672 PDGF-B M. musculus Process P32114 GO:0043010 camera-type eye development TAS 8951055 Pax2 M. musculus Process P32114 GO:0001822 kidney development TAS 8951055 Pax2 M. musculus Process P32114 closure of optic fissure IMP 8951055 Pax2 M. musculus Process P32114 cochlea formation IMP 8951055 Pax2 M. musculus Process P32114 vestibular region morphogenesis IMP 8951055 Pax2 M. musculus Process P32114 organ of Corti cell differentiation IMP 8951055 Pax2 M. musculus Process P35918 positive regulation of angiopoietin-1-Tie2 signaling TAS PUBMED 20406889 VEGFR2 M. musculus Process P37023 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis TAS PUBMED 20406889 dermal microvascular endothelial cells ALK1 H. sapiens "CHO cells, but transfected – article does not state origin of gene" Process P41159 GO:0032099 negative regulation of appetite TAS 17957153 cord leptin Leptin H. sapiens "CHO cells, but transfected – article does not state origin of gene" Process P41159 GO:0048589 developmental growth TAS 17957153 cord leptin Leptin H. sapiens "CHO cells, but transfected – article does not state origin of gene" Process P41159 GO:0048639 positive regulation of developmental growth TAS 17957153 cord leptin Leptin H. sapiens "CHO cells, but transfected – article does not state origin of gene" Process P41159 GO:0001890 placenta development IDA 17957153 cord leptin Leptin H. sapiens Many references in this paragraph Function P42574 GO:0005515 protein binding TAS PUBMED 18548270 PMCA caspase 3 H. sapiens Process P42574 GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA2 caspase 3 H. sapiens Process P42574 GO:0051927 negative regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA2 caspase 3 H. sapiens Process P42574 GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA4 caspase 3 H. sapiens Process P42574 GO:0051927 negative regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PMCA4 caspase 3 H. sapiens Process P43144 GO:0021987 cerebral cortex development TAS PUBMED 20438829 "“nAChRs with the alpha5 subunit may influence cortical activity at these times when neural net-works are being formed. During this period, ethanol has been shown to profoundly depress cortical excitability, reduce responses to somatic sensory stimuli, and delay the occurrence of cortical plasticity for weeks [8,10].”" in the cortex nAChR alpha 5 (nicotinic acetylcholine receptor subunit alpha 5) R. norvegicus Process P43144 GO:0032228 "regulation of synaptic transmission, GABAergic" TAS PUBMED 20438829 “CHRNA5 colocalizes with a subset of GABAergic interneurons in the hippocampus [16] and neocortex and likely contributes to GABAergic synchronicity of network activity [10].” in the neocortex nAChR alpha 5 (nicotinic acetylcholine receptor subunit alpha 5) R. norvegicus Process P43144 late gestational development? TAS PUBMED 20438829 "“Additionally, the subplate, which is a developmentally important cortical structure, also exhibits CHRNA5 expression during late gestation [10]… . …The subplate is required for the formation of thalamo-cortical connections, synaptic remodeling and maturation of the cortex [10]. Adult rats prenatally exposed to ethanol display permanent damages of thalamo-cortical connections as well.”" in the subplate nAChR alpha 5 (nicotinic acetylcholine receptor subunit alpha 5) R. norvegicus Process P43144 GO:0006915 apoptosis TAS PUBMED 20438829 “It has also been suggested that CHRNA5 expression may bemore essential in maturation processes such as apoptosis [10].” nAChR alpha 5 (nicotinic acetylcholine receptor subunit alpha 5) R. norvegicus Process P57Kip2 GO:0002089 lens morphogenesis in camera-type eye TAS 20579985 P57Kip2 ? Process P61809 GO:0021795 cerebral cortex cell migration TAS PUBMED 20624590 Cdk5 M. musculus Process P62158 GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 calmodulin H. sapiens Process P63080 GO:0048589 developmental growth TAS 17021187 GABA-A receptor beta 3 M. musculus Process P63080 GO:0050882 voluntary musculoskeletal movement TAS 17021187 GABA-A receptor beta 3 M. musculus Process P63080 GO:0007611 learning or memory TAS 17021187 GABA-A receptor beta 3 M. musculus Process P63089 GO:0043005 neuron projection TAS PUBMED 10096022 embryonic neurons PTN M. musculus Process P63089 GO:0051919 positive regulation of fibrinolysis TAS PUBMED 10096022 aortic endothelial cells PTN M. musculus Process P63089 GO:0007529 establishment of synaptic specificity at neuromuscular junction TAS PUBMED 10096022 PTN M. musculus Process P78352 GO:0045428 regulation of nitric oxide biosynthetic process NAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ domains on PSD95 H. sapiens Process P78352 GO:0042981 regulation of apoptosis NAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ domains on PSD95 H. sapiens Process P78352 GO:0050999 regulation of nitric-oxide synthase activity NAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ domains on PSD95 H. sapiens Function P78352 GO:0005515 protein binding TAS PUBMED 18548270 PMCA PMCA H. sapiens Process Pax family GO:0009887 organ morphogenesis TAS 8951055 Pax family M. musculus Process Pax family GO:0048729 tissue morphogenesis TAS 8951055 Pax family M. musculus Process Pax6 GO:0007423 sensory organ development TAS 8951055 Pax6 ? Process PDGF GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 PDGF quail Process PDGF GO:0010631 epithelial cell migration TAS PUBMED 20299672 PDGF quail Process PDGF GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 PDGF M. musculus Process PDGF signaling GO:0003347 epicardial cell to mesenchymal cell transition NAS PUBMED 20299672 PDGF signaling M. musculus Function PDGF-AA GO:0005161 platelet-derived growth factor binding TAS PUBMED 20299672 PDGF-AA M. musculus Process PDGF-AA NOT GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation NAS PUBMED 20299672 PDGF-AA quail Process PDGF-AB NOT GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation NAS PUBMED 20299672 PDGF-AB quail Function PDGF-BB GO:0005161 platelet-derived growth factor binding TAS PUBMED 20299672 PDGF-BB M. musculus non-specific ref Process PDGF-BB GO:0061032 visceral serous pericardium development TAS PUBMED 20299672 PDGF-BB G. gallus Process PDGF-BB GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 PDGF-BB G. gallus non-specific ref Process PDGF-BB GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation TAS PUBMED 20299672 PDGF-BB G. gallus Function PDGF-CC GO:0005161 platelet-derived growth factor binding TAS PUBMED 20299672 PDGF-CC M. musculus Function PDGF-DD GO:0005161 platelet-derived growth factor binding TAS PUBMED 20299672 PDGF-DD M. musculus non-specific ref Process PDZ ligand interactions GO:0034621 cellular macromolecular complex subunit organization TAS PUBMED 20431962 neuron-specific "PDZ ligand interactions, including not limited to, NMDA receptor signaling complex" ? non-specific ref Process PDZ ligand on NR2 GO:0045428 regulation of nitric oxide biosynthetic process TAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ ligand on NR2 R. norvegicus Process PDZ ligand on NR2 GO:0042981 regulation of apoptosis TAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ ligand on NR2 R. norvegicus non-specific ref Process PDZ ligand on NR2 GO:0050999 regulation of nitric-oxide synthase activity TAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ ligand on NR2 R. norvegicus Process PDZ ligand on NR2 GO:0045428 regulation of nitric oxide biosynthetic process NAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ ligand on NR2 H. sapiens Process PDZ ligand on NR2 GO:0042981 regulation of apoptosis NAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ ligand on NR2 H. sapiens non-specific ref Process PDZ ligand on NR2 GO:0050999 regulation of nitric-oxide synthase activity NAS PUBMED 20431962 “Coupling of the NMDA receptor NR2 subunit to toxic nitric oxide production and activation of pro-death p38 signalling is mediated by PDZ domains on PSD95 and neuronal nitric oxide synthase and a PDZ ligand on NR2 [34–36] (though this is completely conserved between rodents and humans).” neurons PDZ ligand on NR2 H. sapiens Process phosphatidyinositol-3 kinase pathway GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 phosphatidyinositol-3 kinase pathway quail Function PISP GO:0005515 protein binding TAS PUBMED 18548270 PMCA PMCA H. sapiens Process PKC GO:0051929 positive regulation of calcium ion transport via voltage-gated calcium channel activity TAS PUBMED 18548270 PKC H. sapiens Function PMCA GO:0005388 calcium-transporting ATPase activity TAS PUBMED 17234811 Plasma membrane Ca2 pump R. catesbeiana Component PMCA GO:0060171 stereocilium membrane TAS PUBMED 17234811 Plasma membrane Ca2 pump R. catesbeiana Process PMCA GO:0051283 negative regulation of sequestering of calcium ion TAS PUBMED 17234811 Plasma membrane Ca2 pump R. catesbeiana Process PMCA GO:0045299 otolith mineralization TAS PUBMED 17234811 Plasma membrane Ca2 pump M. musculus Process PMCA GO:0043583 ear development TAS PUBMED 17234811 Plasma membrane Ca2 pump M. musculus Process PMCA GO:0007605 sensory perception of sound TAS PUBMED 17234811 Plasma membrane Ca2 pump M. musculus Function PMCA GO:0005388 calcium-transporting ATPase activity TAS PUBMED 18548270 PMCA ? Function PMCA GO:0006874 cellular calcium ion homeostasis TAS PUBMED 18548270 PMCA ? Function PMCA GO:0009925 basal plasma membrane TAS PUBMED 18548270 PMCA ? Component PMCA GO:0005887 integral to plasma membrane TAS PUBMED 18548270 PMCA ? Function PMCA GO:0005509 calcium ion binding TAS PUBMED 18548270 PMCA H. sapiens Function PMCA GO:0022828 phosphorylation-gated channel activity TAS PUBMED 18548270 PMCA C. l. familiarus Function PMCA GO:0051018 protein kinase A binding TAS PUBMED 18548270 PMCA ? Function PMCA GO:0005080 protein kinase C binding TAS PUBMED 18548270 PMCA ? Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 calpain PMCA H. sapiens Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 caspase 1 PMCA H. sapiens Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 caspase 3 PMCA H. sapiens Function PMCA GO:0046983 protein dimerization activity TAS PUBMED 18548270 PMCA H. sapiens Function PMCA GO:0030165 PDZ domain binding TAS PUBMED 18548270 PMCA H. sapiens Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 MAGUK family PMCA ? Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 SAP PMCA H. sapiens Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 CASK PMCA ? Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 Na+/H+ exchanger regulatory factor 2 PMCA H. sapiens Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 PISP PMCA H. sapiens Function PMCA GO:0005515 protein binding TAS PUBMED 18548270 Ania3/Homer protein PMCA ? Process PMCA GO:0043066 negative regulation of apoptosis TAS PUBMED 18548270 PMCA4 M. musculus PMCA1 (expression info) PUBMED 18548270 most tissues PMCA1 Process PMCA1 """critical housekeeping function""" PUBMED 18548270 PMCA1 M. musculus PMCA2 (expression info) PUBMED 18548270 "brain, striated muscle, uterus, liver, kidney, lactating mammary glands, specialized cells such as cerebellar Purkinje neurons and cochlear hair cells" PMCA2 Process PMCA2 GO:0050973 detection of mechanical stimulus involved in equilibrioception TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0048839 inner ear development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0090102 cochlea development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0031173 otolith mineralization completed early in development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0060117 auditory receptor cell development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0048666 neuron development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0051928 positive regulation of calcium ion transport TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0006874 cellular calcium ion homeostasis TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 Calcium export from cell TAS PUBMED 18548270 hair cells PMCA2 M. musculus Process PMCA2 opening of MET (mechanoelectric transport) channels TAS PUBMED 18548270 hair cells PMCA2 M. musculus Process PMCA2 Calcium export into milk TAS PUBMED 18548270 mammary gland PMCA2 M. musculus Process PMCA2 spinal cord motor neuron survival/proliferation TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 purkinje neuron morphogenesis/development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0021680 cerebellar Purkinje cell layer development TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0021692 cerebellar Purkinje cell layer morphogenesis TAS PUBMED 18548270 PMCA2 M. musculus Process PMCA2 GO:0021517 ventral spinal cord development TAS PUBMED 18548270 PMCA2 M. musculus PMCA3 (expression info) PUBMED 18548270 "brain and striated muscle, choroid plexus" PMCA3 PMCA4 (expression info) PUBMED 18548270 most tissues PMCA4 Process PMCA4 male fertility TAS PUBMED 18548270 PMCA4 M. musculus Process PMCA4 GO:0051562 reduction of mitochondrial calcium ion concentration TAS PUBMED 18548270 PMCA4 M. musculus Process PMCAs GO:0006874 cellular calcium ion homeostasis PUBMED 9668038 PMCAs ? Process PMCAs GO:0048666 neuron development PUBMED 18548270 PMCAs H. sapiens Process PMCAs GO:0014042 positive regulation of neuron maturation PUBMED 18548270 PMCAs H. sapiens Function prototypical ALK5 GO:0005160 transforming growth factor beta receptor binding TAS PUBMED 18461597 TGFb type II receptor (TbRII) prototypical activin receptor-like kinase 5 ? Process Q00651 Coronary plexus dev TAS PUBMED 20299672 Integrin alpha 4 M. musculus Process Q00651 GO:0060976 coronary vasculature development NAS PUBMED 20299672 Integrin alpha 4 M. musculus Process Q00731 GO:0001525 angiogenesis TAS PUBMED 20299672 VEGF-A M. musculus Process Q01814 GO:0007605 sensory perception of sound TAS PUBMED 17234811 PMCA2 Plasma membrane Ca2 pump type 2 H. sapiens Process Q02858 positive regulation of angiopoietin-1-Tie2 signaling TAS PUBMED 20406889 Tie2 M. musculus Process Q02858 GO:0043066 negative regulation of apoptosis TAS PUBMED 20406889 Tie2 tyrosine kinase receptor M. musculus Process Q02962 GO:0043010 camera-type eye development TAS 8951055 Pax2 H. sapiens Process Q02962 GO:0001822 kidney development TAS 8951055 Pax2 H. sapiens Process Q03347 positive reg differentiation of bTUB (beta tubulin) expressing cells IMP 20187849 Runx1 M. musculus Process Q03347 GO:0030182 neuron differentiation IMP 20187849 Runx1 M. musculus Process Q03347 GO:0010001 glial cell differentiation IMP 20187849 Runx1 M. musculus Process Q03347 GO:0009790 embryo development IMP 20187849 Runx1 M. musculus Process Q03347 GO:0040010 positive regulation of growth rate IMP 20187849 Runx1 M. musculus Process Q03347 GO:0043473 pigmentation IMP 20187849 Runx1 M. musculus Process Q03347 GO:0048546 digestive tract morphogenesis IMP 20187849 Runx1 M. musculus Process Q03347 dorsal root ganglion morphogenesis IMP 20187849 Runx1 M. musculus Process Q03347 GO:0051930 regulation of sensory perception of pain IMP 20187849 positive regulation Runx1 M. musculus Process Q0VGT2 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 Gli2 M. musculus Function Q13402 GO:0005515 protein binding TAS PUBMED 17234811 harmonin Q9Y6N9 myosin VIIa H. sapiens Function Q15599 GO:0005515 protein binding TAS PUBMED 18548270 PMCA PMCA H. sapiens Process Q30201 negative regulation of fetal birth weight IMP 19711434 in males HFE H. sapiens Process Q30201 GO:0060586 multicellular organismal iron ion homeostasis TAS 19711434 HFE H. sapiens Process Q30201 decreased risk of Acute Lymphoblastic Leukemia IMP 19711434 in females HFE H. sapiens Process Q62351 release of carboxy-terminal collagen crosslinks (CTX) IDA 19252502 tfr1 M. musculus Function Q811J3 GO:0005515 protein binding IDA 19252502 IRE IRP2 M. musculus Function Q86SR7 GO:0005515 protein binding IPI PUBMED 20624590 Tuj1 (beta 3 tubulin specific to neurons) Disrupted in schizophrenic M. musculus Function Q86SR7 GO:0003779 actin binding TAS PUBMED 20624590 Disrupted in schizophrenic M. musculus Process Q8BSQ9 GO:0035425 autocrine signaling NAS PUBMED 20299672 Protein polybromo-1 (BAF180) M. musculus Process Q8BSQ9 GO:0003347 epicardial cell to mesenchymal cell transition NAS PUBMED 20299672 Protein polybromo-1 (BAF180) M. musculus Process Q8CFN5 GO:0030900 forebrain development IEP 7643214 myocyte enhancer factor 2c (Mef2c) M. musculus Process Q8CFN5 GO:0021772 olfactory bulb development IEP 7643214 myocyte enhancer factor 2c (Mef2c) M. musculus Function Q8CI19 GO:0042803 protein homodimerization activity NAS PUBMED 20299672 PDGF-C M. musculus Function Q8CI19 GO:0048407 platelet-derived growth factor binding NAS PUBMED 20299672 PDGF-C M. musculus Function Q8VBX6 NOT GO:0005515 protein binding TAS PUBMED 20431962 C-terminal PDZ ligand of human somatostatin receptor 3 PDZ protein MUPP1 M. musculus Process Q8VHJ7 osteoclast morphology IMP 19252502 ppargc1b M. musculus Process Q8VHJ7 positive regulation of mitochondrial enzyme function IMP 19252502 ppargc1b M. musculus Process Q8VHJ7 osteoclast development IMP 19252502 ppargc1b M. musculus Process Q8VHJ7 positive regulation of osteoclast function IMP 19252502 ppargc1b M. musculus Process Q8VHJ7 positive regulation of osteoclast actin ring formation IMP 19252502 ppargc1b M. musculus Process Q8VHJ7 mitochondrial oxidative energy metabolism TAS 19252502 ppargc1b M. musculus Process Q90751 GO:0060317 cardiac epithelial to mesenchymal transition TAS PUBMED 18461597 BMP2 G. gallus Process Q90751 GO:0010718 positive regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 BMP2 G. gallus Process Q90751 GO:0010718 positive regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 BMP2 G. gallus Process Q921I1 positive regulation of osteoclast actin ring formation IDA 19252502 transferrin (tf) M. musculus Function Q925I7 GO:0042803 protein homodimerization activity NAS PUBMED 20299672 PDGF-D M. musculus Function Q925I7 GO:0048407 platelet-derived growth factor binding NAS PUBMED 20299672 PDGF-D M. musculus Process Q99M75 GO:0045202 synapse TAS 20463223 central synapse Nogo receptor 1 R. norvegicus Process Q99PI8 GO:0045202 synapse TAS 20463223 central synapse Nogo receptor 1 M. musculus Process Q99PI8 GO:0060997 dendritic spine morphogenesis TAS 20463223 central synapse Nogo receptor 1 M. musculus Process Q99PI8 GO:0007613 memory TAS 20463223 central synapse Nogo receptor 1 M. musculus Process Q9H251 GO:0007605 sensory perception of sound TAS PUBMED 17234811 Cadherin 23 H. sapiens Function Q9H251 GO:0005515 protein binding TAS PUBMED 17234811 harmonin Q9Y6N9 Cadherin 23 H. sapiens Process Q9NPI1 GO:0016049 cell growth NAS 18071067 BRD7 (bromodomain) H. sapiens Process Q9NPI1 GO:0007049 cell cycle NAS 18071067 BRD7 (bromodomain) H. sapiens Process Q9NPI1 GO:0010467 gene expression NAS 18071067 BRD7 (bromodomain) H. sapiens Process Q9QZR5 retina ganglion patterning IMP 20579985 Hipk2 M. musculus Process Q9QZR5 GO:0043065 positive regulation of apoptosis TAS 20579985 Hipk2 ? Process Q9QZR5 GO:0032582 negative regulation of gene-specific transcription TAS 20579985 CtBP Hipk2 ? Process Q9QZR5 GO:0032583 regulation of gene-specific transcription TAS 20579985 Apaf1 Hipk2 ? Process Q9UBU3 GO:0048639 positive regulation of developmental growth TAS 17957153 cord ghrelin Ghrelin H. sapiens Function Q9UK05 GO:0005515 protein binding TAS PUBMED 20406889 with ALK-1 Endothelial cells Bone Morphogenetic Protein 9 (BMP-9) H. sapiens Function Q9UK05 GO:0005515 protein binding TAS PUBMED 20406889 with Endoglin Endothelial cells Bone Morphogenetic Protein 9 (BMP-9) H. sapiens Process Q9UK05 GO:0060389 pathway-restricted SMAD protein phosphorylation TAS PUBMED 20406889 with Smad1 Bone Morphogenetic Protein 9 (BMP-9) H. sapiens Process Q9UK05 GO:0060389 pathway-restricted SMAD protein phosphorylation TAS PUBMED 20406889 with Smad5 Bone Morphogenetic Protein 9 (BMP-9) H. sapiens Process Q9UK05 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis TAS PUBMED 20406889 dermal microvascular endothelial cells Bone Morphogenetic Protein 9 (BMP-9) H. sapiens Process Q9UK05 NOT GO:0001558 regulation of cell growth IDA PUBMED 20406889 pancreatic cancer cells BMP-9 H. sapiens Process Q9WV56 adult angiogenesis IDA PUBMED 20406889 BMP-9 M. musculus Process Q9WV56 tumor angiogenesis TAS PUBMED 20406889 "lung, breast" BMP-9 M. musculus Function Q9Y6N9 GO:0005515 protein binding TAS PUBMED 17234811 cadherin23 Q9H251 harmonin H. sapiens Function Q9Y6N9 GO:0005515 protein binding TAS PUBMED 17234811 myosin VIIa Q13402 harmonin H. sapiens Process reactive oxygen species GO:0043193 positive regulation of gene-specific transcription IDA 19252502 ppargc1b reactive oxygen species M. musculus Process reactive oxygen species GO:0045672 positive regulation of osteoclast differentiation IDA 19252502 reactive oxygen species M. musculus Process reactive oxygen species GO:0006390 transcription from mitochondrial promoter IDA 19252502 reactive oxygen species M. musculus Process Retanoic acid signaling GO:0007165 signal transduction NAS PUBMED 20299672 Retanoic acid signaling ? Component Retanoic acid signaling GO:0005634 nucleus NAS PUBMED 20299672 Retanoic acid signaling ? Function Retanoic acid signaling GO:0042562 hormone binding NAS PUBMED 20299672 Retanoic acid signaling ? ? Function Retanoic acid signaling GO:0051427 hormone receptor binding NAS PUBMED 20299672 Retanoic acid signaling ? ? Process Retinoic acid GO:0060045 positive regulation of cardiac muscle cell proliferation NAS PUBMED 20299672 Retinoic acid G. gallus ? Process Retinoic acid GO:0003007 heart morphogenesis TAS PUBMED 20299672 Retinoic acid M. musculus Process retinoic acid posterior positional identity of neuron differentiation TAS PUBMED 20431962 “Neurons generated from hESCs under chemically defined conditions in the absence of exogenous morphogens including retinoic acid tend to differentiate towards an anterior positional identity [10] as has been found for mouse hESCs [11].” in the brain retinoic acid H. sapiens Process Retinoic acid receptor GO:0007165 signal transduction NAS PUBMED 20299672 Retinoic acid receptor ? Component Retinoic acid receptor GO:0005634 nucleus NAS PUBMED 20299672 Retinoic acid receptor ? Function Retinoic acid receptor GO:0042562 hormone binding NAS PUBMED 20299672 Retinoic acid receptor ? Function Retinoic acid receptor GO:0051427 hormone receptor binding NAS PUBMED 20299672 Retinoic acid receptor ? Process Retinoic acid signaling GO:0060045 positive regulation of cardiac muscle cell proliferation TAS PUBMED 20299672 Retinoic acid signaling G. gallus Process Retinoid signaling GO:0009790 embryonic development NAS PUBMED 20299672 Retinoid signaling Quail Process Retinoid signaling GO:0007507 heart development TAS PUBMED 20299672 Retinoid signaling Quail Process Retinoid signaling GO:0001947 heart looping TAS PUBMED 20299672 Retinoid signaling Process Retinoid signaling GO:0060038 cardiac muscle cell proliferation TAS PUBMED 20299672 Retinoid signaling General Process Retinoid signaling GO:0055007 cardiac muscle cell differentiation TAS PUBMED 20299672 Retinoid signaling General Process RhoA GO:0032583 regulation of gene-specific transcription TAS PUBMED 18461597 ROCK RhoA G. gallus Process Rho-ROCK pathway GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 Rho-ROCK pathway M. musculus Process Rho-ROCK pathway GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 Rho-ROCK pathway G. gallus Process ROCK1 GO:0007266 Rho protein signal transduction TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK1 GO:0030036 actin cytoskeleton organization TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK1 GO:0008283 cell proliferation TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK1 GO:0070252 actin-mediated cell contraction TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK1 GO:0060327 cytoplasmic actin-based contraction involved in cell TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK1 GO:0060317 cardiac epithelial to mesenchymal transition IDA PUBMED 18461597 ROCK G. gallus Process ROCK1 GO:0060973 cell migration involved in heart development IDA PUBMED 18461597 ROCK G. gallus Process ROCK2 GO:0007266 Rho protein signal transduction TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK2 GO:0030036 actin cytoskeleton organization TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK2 GO:0008283 cell proliferation TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK2 GO:0070252 actin-mediated cell contraction TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process ROCK2 GO:0060327 cytoplasmic actin-based contraction involved in cell TAS PUBMED 18461597 "Rho kinases (ROCK1, ROCK2)" B. taurus Process Runx1a negative reg differentiation of bTUB expressing cells IMP 20187849 Runx1a M. musculus Process Runx1a GO:0010001 glial cell differentiation IMP 20187849 Runx1a M. musculus Process Runx1a GO:0045665 negative regulation of neuron differentiation IMP 20187849 Runx1a M. musculus Process Runx1a GO:0045665 negative regulation of neuron differentiation IMP 20187849 Runx1a M. musculus Process Runx1a GO:0048546 digestive tract morphogenesis IMP 20187849 Runx1a M. musculus Process Runx1a dorsal root ganglion morphogenesis IMP 20187849 Runx1a M. musculus Process Runx1a negative regulation of sensory perception of pain IMP 20187849 Runx1a M. musculus Process RXR GO:0007165 signal transduction NAS PUBMED 20299672 RXR ? Component RXR GO:0005634 nucleus NAS PUBMED 20299672 RXR ? Function RXR GO:0042562 hormone binding NAS PUBMED 20299672 RXR ? Function RXR GO:0051427 hormone receptor binding NAS PUBMED 20299672 RXR ? Process RXR GO:0046982 protein heterodimerization activity NAS PUBMED 20299672 RXR ? Function SERCA GO:0005388 calcium-transporting ATPase activity TAS PUBMED 18548270 SERCA ? Function SERCA GO:0006874 cellular calcium ion homeostasis TAS PUBMED 18548270 SERCA ? Function SERCA GO:0009925 basal plasma membrane TAS PUBMED 18548270 SERCA ? Process Slit GO:0007411 axon guidance TAS 20463223 Slit ? Process Slit axon repulsion TAS 20463223 Slit ? Process Slit axon growth cone collapse TAS 20463223 Slit ? Process TGF beta GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 TGF beta M. musculus Process TGF beta GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 of ALK-5-Smad2/3 TGF beta M. musculus Process TGF beta GO:0060395 SMAD protein signal transduction TAS PUBMED 20406889 of ALK-1-Smad1/5/8 TGF beta M. musculus "From now on, putting ALL mouse annotations in GONE" Process TGF beta GO:0010596 negative regulation of endothelial cell migration TAS PUBMED 20406889 TGF beta M. musculus Process TGF beta GO:0001937 negative regulation of endothelial cell proliferation TAS PUBMED 20406889 TGF beta M. musculus Process TGF beta GO:0010595 positive regulation of endothelial cell migration TAS PUBMED 20406889 TGF beta M. musculus Process TGF beta GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 TGF beta M. musculus Process TGF beta GO:0042118 endothelial cell activation TAS PUBMED 20406889 TGF beta M. musculus Process TGF beta GO:0010717 regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 Transforming growth factor beta M. musculus Process TGF beta GO:0001837 epithelial to mesenchymal transition TAS PUBMED 18461597 transforming growth factor beta G. gallus Process TGF beta activation of ALK5 GO:0060947 : cardiac vascular smooth muscle cell differentiation NAS PUBMED 20299672 TGF beta activation of ALK5 M. musculus Process TGF beta activation of ALK5 GO:0001974 blood vessel remodeling NAS PUBMED 20299672 TGF beta activation of ALK5 M. musculus Process TGF beta family GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 TGF beta family M. musculus Process TGF beta ligands GO:0003347 epicardial cell to mesenchymal cell transition TAS PUBMED 20299672 TGF beta ligands M. musculus Process TGF beta receptors GO:0010717 regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 Transforming growth factor beta receptors M. musculus Function TGFb GO:0005515 protein binding TAS PUBMED 18461597 "ALK2, in the presence of type II TGFb receptor" transforming growth factor beta G. gallus Function TGFb GO:0005515 protein binding TAS PUBMED 18461597 "ALK5, in the presence of type II TGFb receptor" transforming growth factor beta G. gallus Process TGFb GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation TAS PUBMED 18461597 transforming growth factor beta ? Process TGFbeta GO:0032583 regulation of gene-specific transcription TAS PUBMED 18461597 "RhoA, ROCK" transforming growth factor beta G. gallus Process TGF-beta in general GO:0060731 positive regulation of intestinal epithelial structure maintenance IMP 20875417 decreased damage in NEC and hypoxic environment TGF-beta M. musculus Process TGF-beta signaling pathway GO:0043010 camera-type eye development TAS 20579985 TGF-beta signaling pathway ? Process TGFbR1 (ALK5) GO:0060317 cardiac epithelial to mesenchymal transition TAS PUBMED 18461597 TGF beta type 1 receptor (activin receptor-like kinase 5) G. gallus Process TGFbs GO:0010718 positive regulation of epithelial to mesenchymal transition TAS PUBMED 18461597 TGFbeta family G. gallus Process Tie2 tyrosine kinase receptor GO:0043066 negative regulation of apoptosis TAS PUBMED 20406889 Tie2 tyrosine kinase receptor R. norvegicus Process TRPV2 GO:0045773 positive regulation of axon extension IMP 20357111 TRPV2 G. gallus Process VDAC GO:0043193 positive regulation of gene-specific transcription IMP PUBMED 20797405 CKB Q04447 Voltage-dependent anion-selective channel protein 1 M. musculus Process VDAC GO:0043193 positive regulation of gene-specific transcription IMP PUBMED 20797405 creatine-phosphocreatine curcuit Voltage-dependent anion-selective channel protein 1 M. musculus VDAC auditory neurons PUBMED 20797405 Voltage-dependent anion-selective channel protein 1 M. musculus Process VEGF GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20299672 VEGF quail human gene in mouse Process VEGF GO:0010595 positive regulation of endothelial cell migration TAS PUBMED 20299672 VEGF quail human gene in mouse Process VEGF GO:0035148 tube formation TAS PUBMED 20299672 VEGF quail human gene in mouse Process VEGF GO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS PUBMED 20299672 VEGF Quail Process VEGF GO:0003248 heart capillary growth TAS PUBMED 20299672 VEGF Quail Process VEGF GO:0045765 regulation of angiogenesis TAS PUBMED 20299672 VEGF M. musculus Process VEGF GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS PUBMED 20406889 VEGF-VEGFR2 VEGF M. musculus Process VEGF positive regulation of angiopoietin-1-Tie2 signaling TAS PUBMED 20406889 VEGF M. musculus Process VEGF GO:0010595 positive regulation of endothelial cell migration TAS PUBMED 20406889 VEGF M. musculus Process VEGF GO:0001936 regulation of endothelial cell proliferation TAS PUBMED 20406889 VEGF M. musculus Process VEGF GO:0043193 positive regulation of gene-specific transcription IDA PUBMED 20406889 of "PECAM1, ALK1, endoglin" ESC-derived vascular endothelial cell progenitors VEGFR2+ VEGF M. musculus Process VEGF GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 VEGF M. musculus Process VEGF GO:0043542 endothelial cell migration TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGF M. musculus Process VEGF GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 VEGF R. norvegicus Process VEGF GO:0043542 endothelial cell migration TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGF R. norvegicus Process VEGF GO:0030509 BMP signaling pathway NAS PUBMED 20406889 VEGF M. musculus Process VEGF signaling GO:0045766 positive regulation of angiogenesis IDA PUBMED 20406889 VEGF signaling M. musculus Process VEGF signaling GO:0030513 positive regulation of BMP signaling pathway IDA PUBMED 20406889 VEGF signaling M. musculus PBT project (11.30.10) Process VEGFR2 GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGFR2 M. musculus After PBT project Process VEGFR2 GO:0043542 endothelial cell migration TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGFR2 M. musculus Process VEGFR2 GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGFR2 R. norvegicus Process VEGFR2 GO:0043542 endothelial cell migration TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGFR2 R. norvegicus Process VEGF-VEGFR2 GO:0042118 endothelial cell activation TAS PUBMED 20406889 VEGF-VEGFR2 M. musculus Process VEGF-VEGFR2 signaling pathways GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGF-VEGFR2 signaling pathways M. musculus Process VEGF-VEGFR2 signaling pathways GO:0043542 endothelial cell migration TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGF-VEGFR2 signaling pathways M. musculus Process VEGF-VEGFR2 signaling pathways GO:0001938 positive regulation of endothelial cell proliferation TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGF-VEGFR2 signaling pathways R. norvegicus Process VEGF-VEGFR2 signaling pathways GO:0043542 endothelial cell migration TAS PUBMED 20406889 "“VEGF-VEGFR2 signaling pathways are known to stimulate endothelial proliferation, survival and migration. Ang-1 is an agonist for the Tie2 tyrosine kinase receptor, which inhibits apoptosis of endothelial cells (Maisonpierre et al., 1997; Holash et al., 1999).”" VEGF-VEGFR2 signaling pathways R. norvegicus Process Wnt signaling pathway GO:0043010 camera-type eye development TAS PUBMED 20579985 Wnt signaling pathway ? Process Wnt/wingless signaling pathway GO:0007507 heart development TAS PUBMED 20299672 Wnt/wingless signaling pathway M. musculus Function XXXXXX EXAMPLE GO:0003677 DNA binding TAS PUBMED 8246913 EXAMPLE EXAMPLE EXAMPLE EXAMPLE EXAMPLE EXAMPLE Process Q99958 GO:0001568 blood vessel development TAS PUBMED 21457232 FOXC2 H. sapiens Process Q12952 GO:0001568 blood vessel development TAS PUBMED 21457232 FOXL1 H. sapiens Process P52952 GO:0060413 atrial septum morphogenesis TAS PUBMED 21457232 NKX2-5 H. sapiens Process O96004 GO:0007507 heart development TAS PUBMED 21457232 HAND1 H. sapiens Process Q64279 GO:0007507 heart development TAS PUBMED 21457232 HAND1 M. musculus Process P46531 GO:0003176 aortic valve development TAS PUBMED 21457232 NOTCH1 H. sapiens Process Q01705 GO:0003176 aortic valve development TAS PUBMED 21457232 NOTCH1 M. musculus Process Q9BX79 GO:0060900 embryonic camera-type eye formation TAS PUBMED 19500772 STRA6 H. sapiens Process Q9BX79 GO:0030324 lung development TAS PUBMED 19500772 STRA6 H. sapiens Process Q9BX79 GO:0001701 in utero embryonic development TAS PUBMED 19500772 STRA6 H. sapiens Q12946 ductus arteriosus closure IMP PUBMED 19500772 FOXF1 H. sapiens Process P58304 GO:0060900 embryonic camera-type eye formation TAS PUBMED 17273977 CHX10 H. sapiens Process P58304 GO:0031076 embryonic camera-type eye development TAS PUBMED 17273977 CHX10 H. sapiens Process P48431 GO:0031076 embryonic camera-type eye development TAS PUBMED 17273977 SOX2 H. sapiens Q9BX79 ductus arteriosus closure IMP PUBMED 17273977 STRA6 H. sapiens Q9BX79 jaw development IMP PUBMED 17273977 STRA6 H. sapiens Q9BX79 hair pattern development (eyebrows) IMP PUBMED 17273977 STRA6 H. sapiens Q9BX79 ear placement IMP PUBMED 17273977 STRA6 H. sapiens P49639 cochlea formation IMP PUBMED 16155570 HOXA1 H. sapiens P49639 vestibule formation IMP PUBMED 16155570 HOXA1 H. sapiens P49639 semi-circular canal formation IMP PUBMED 16155570 HOXA1 H. sapiens P49639 carotid canal formation IMP PUBMED 16155570 HOXA1 H. sapiens P49639 internal carotid artery formation IMP PUBMED 16155570 HOXA1 H. sapiens P09022 GO:0021594 rhombomere formation TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0001755 neural crest cell migration TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0022008 neurogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0021603 cranial nerve formation TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0021598 abducens nerve morphogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0021610 facial nerve morphogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0021719 superior olivary nucleus morphogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0048839 inner ear development TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0021602 cranial nerve morphogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0042473 outer ear morphogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0048701 embryonic cranial skeleton morphogenesis TAS PUBMED 16155570 Hoxa1 M. musculus P09022 GO:0007585 respiratory gaseous exchange TAS PUBMED 16155570 Hoxa1 M. musculus P49639 GO:0002087 regulation of respiratory gaseous exchange by neurological system process TAS PUBMED 16155570 HOXA1 H. sapiens P49639 GO:0003007 heart morphogenesis TAS PUBMED 16155570 HOXA1 H. sapiens P49639 GO:0035909 aorta morphogenesis TAS PUBMED 16155570 HOXA1 H. sapiens P49639 GO:0003016 respiratory system process TAS PUBMED 21784065 HOXA1 H. sapiens P49639 GO:0007605 sensory perception of sound TAS PUBMED 21784065 HOXA1 H. sapiens P49639 swallowing TAS PUBMED 21784065 HOXA1 H. sapiens P49639 vocal cord function TAS PUBMED 21784065 HOXA1 H. sapiens P49639 facial neuromuscular function TAS PUBMED 21784065 HOXA1 H. sapiens P49639 GO:0003151 outflow tract morphogenesis TAS PUBMED 21784065 HOXA1 H. sapiens ABCB1 GO:0005215 transporter activity TAS PUBMED 19384922 ABCB1 check ABCB1 GO:0009636 response to toxin TAS PUBMED 19384922 ABCB1 check ABCB1 GO:0005215 transporter activity TAS PUBMED 19384922 "in the brain, kidney liver, intestine, adrenal gland" ABCB1 check ABCB1 GO:0007588 excretion TAS PUBMED 19384922 "in the kidney, liver, intestine, adrenal gland" ABCB1 check P46821 GO:0000226 microtubule cytoskeleton organization TAS PUBMED 19567321 MAP1B H. sapiens P46821 GO:0007399 nervous system development TAS PUBMED 19567321 MAP1B H. sapiens P46821 GO:0007409 axonogenesis TAS PUBMED 19567321 MAP1B H. sapiens Q06787 GO:0010468 regulation of gene expression TAS PUBMED 19567321 MAP1B FMRP H. sapiens P11137 GO:0007409 neuron projection development TAS PUBMED 19567321 MAP2 H. sapiens P10636 GO:0007409 neuron projection development TAS PUBMED 19567321 MAP2 H. sapiens P29533 GO:0005515 protein binding TAS PUBMED 20299672 Vcam1 M. musculus Q02858 GO:0005515 protein binding TAS PUBMED 20299672 Tek M. musculus P12643 GO:0060349 bone morphogenesis TAS PUBMED 22540193 BMP2 H. sapiens H0YLW3 GO:0060349 bone morphogenesis TAS PUBMED 22540193 BMP4 H. sapiens P22004 GO:0060349 bone morphogenesis TAS PUBMED 22540193 BMP6 H. sapiens B1AL00 GO:0060349 bone morphogenesis TAS PUBMED 22540193 BMP7 H. sapiens H3BMP9 GO:0060349 bone morphogenesis TAS PUBMED 22540193 BMP9 H. sapiens